Photoreactivating-enzyme activity in metazoa.
نویسندگان
چکیده
منابع مشابه
Photoreactivating-enzyme activity in metazoa.
Photoreactivation of ultraviolet (UV) radiation damage to organisms has been demonstrated in many plant and animal phyla.1 In a few cases, this repair process has been shown to involve a light-dependent photoreactivating enzyme which monomerizes U1-induced pyrimidine dimers in DNA.2 3 However, the biological phenomenon of photoreactivation does not necessarily indicate the involvement of a phot...
متن کاملEvidence for lack of DNA photoreactivating enzyme in humans.
Photoreactivating enzyme (DNA photolyase; deoxyribocyclobutadipyrimidine pyrimidine-lyase, EC 4.1.99.3) repairs UV damage to DNA by utilizing the energy of near-UV/visible light to split pyrimidine dimers into monomers. The enzyme is widespread in nature but is absent in certain species in a seemingly unpredictable manner. Its presence in humans has been a source of considerable controversy. To...
متن کاملXeroderma pigmentosum cells contain low levels of photoreactivating enzyme.
Fibroblasts from patients with xeroderma pigmentosum contain low levels of photoreactivating enzyme in comparison to normal cells. Levels vary from 0 (line 1199) to 50 (line 1259) percent of normal. The depressed enzyme levels are not an artifact of low growth rate, age of cell donor, cell culture conditions, assay conditions, the presence of inhibitors, or mycoplasma contamination. We show tha...
متن کاملAbsence of photoreactivating enzyme in Candida albicans. Candida stellatoidea, and Candida tropicalis.
In vitro assays demonstrate photoreactivating enzyme activity in extracts of Candida pseudotropicalis but not in extracts of Candida albicans, Candida stellatoidea, or Candida tropicalis.
متن کاملUnscheduled DNA synthesis in xeroderma pigmentosum cells after microinjection of yeast photoreactivating enzyme.
Photoreactivating enzyme (PRE) from yeast causes a light-dependent reduction of UV-induced unscheduled DNA synthesis (UDS) when injected into the cytoplasm of repair-proficient human fibroblasts (Zwetsloot et al., 1985). This result indicates that the exogenous PRE monomerizes UV-induced dimers in these cells competing with the endogenous excision repair. In this paper we present the results of...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1967
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.58.4.1359